The Best Ingredients For The Best Results

gsh-gold-ingredient list and label

GSH Gold Ingredient Breakdown

Setria® L-Glutathione (Reduced)

Referred to as the body’s Master Antioxidant, glutathione is one of the most important molecules for detoxification, repair and maintenance of our body and cells. In fact, glutathione levels are measured in order to determine an individual’s overall body toxicity.

Supplementing L-glutathione orally is an effective way to increase your GSH levels. [1] Improved glutathione levels benefit virtually every bodily system and function, playing an integral role in mitochondrial health and fighting oxidative damage and free radical formation. [2]

More on Glutathione…

L-Glutathione-Dietary-Source
N-Acetylcysteine-dietary-sources

N acetyl-L-cysteine

In order to produce glutathione naturally, our body requires three different amino acids; glycine, glutamic acid and cysteine. Cysteine is the rate limiting factor, meaning the other two amino acids are readily available. Supplementing cysteine in a usable form like N acetyl-L-cysteine will help improve the body’s natural production of glutathione.

N acetyl-L-cysteine yields extraordinary benefits beyond enhancing our glutathione levels. It has been found to lower homocysteine levels and reduce oxidative stress, two leading causes of disease and illness. [3] NAC has proven to help minimize the symptoms associated with the influenza virus, as well as inhibiting the proliferation of the virus. [4]

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Alpha lipoic acid

A powerful antioxidant found in every cell in the body. Alpha lipoic acid is needed by our cells to help convert glucose into energy and minimize free radical damage.

Alpha lipoic acid or ALA is unique in that it is both fat and water soluble. While many antioxidants are only capable of reaching certain cells, alpha lipoic acid has free reign to reach virtually every cell in the body.

Cellular energy is a critical component in overall health, making alpha lipoic acid an extremely important antioxidant. ALA has been used to help treat diabetics due to its effects on insulin sensitivity, as well as helping obese patients lose excess body fat. [5,6] It also aids in muscle regeneration and cognitive health, truly a remarkable supplement with profound health benefits. [7,8]

More on Alpha Lipoic Acid…

Alpha-Lipoic-Acid-Dietary-Sources

Acetyl L-carnitine

A widely recognized energy supplement, Acetyl L-carnitine or ALC is commonly used to improve energy levels and quality of life in patients with a variety of health conditions. [9]

Acetyl L-carnitine plays a key role in cellular metabolism, transporting fatty acids to the mitochondria to be broken down. When someone is deficient in carnitine it can lead to a decreased ability to utilize long chain fatty acids as energy. [10]

The biologically active form of carnitine is L-carnitine, which is widely used as a natural dietary supplement. Popular among fitness enthusiasts due to its role in cellular metabolism and energy production, Acetyl L-carnitine also holds immense neurological and cognitive benefits. [11]

acetyl-l-carnitine-dietary-sources

Selenium (L-selenomethionine)

Selenium is an important trace element, acting as a cofactor in 3 of the 4 known thyroid hormones that are responsible for switching various other thyroid hormones on or off. This plays a significant role in the body’s hormonal balance and development.

GSH is also a benefactor of selenium’s profound benefits because selenium is also a cofactor for the reduction of many antioxidants, including GSH. [12] Ensuring optimal selenium levels is important for our hormonal balance, antioxidant function and methylation cycle, all working together to keep our health in check.

Selenium-Dietary-Sources
bioperine-piperine-extract-health-supplement

Bioperine®

A patented extract from the black pepper fruit, Bioperine® is a natural thermonutrient capable of significantly increasing the body’s ability to absorb nutrients. Contributing to gut health as well as boosting the bioavailability of nutrients, Bioperine® helps ensure you’re getting the absolute most out of your supplements.

GSH Gold has 5 mg of Bioperine® per dose to enhance the absorption and efficacy of the formula as a whole. The thermogenic effects of Bioperine® aid in every metabolic process and can even help with weight management.

Milk thistle

Silymarin is the potent extract from the milk thistle plant, commonly found in dietary and herbal supplements. It is so common because it is believed to hold powerful liver health benefits, helping to detoxify the body and improve overall health. Much of this benefit is thought to be because of milk thistle’s ability to increase glutathione while reducing lipid peroxidation. [13]

Milk thistle is a kind of herbal heal all, able to promote organ health and detoxify the body. It has even been shown to alleviate the symptoms of allergic rhinitis or Hay Fever. [14] Supplementing with milk thistle can yield a wide range of health benefits due to its GSH promoting qualities and ability to minimize oxidative stress.

Dietary-sources-of-CoQ10

Ubiquinol CoQ10

Coenzyme Q10 has three different forms, the fully oxidized form known as ubiquinone, the partially oxidized form, ubisemiquinone and the fully reduced form, ubiquinol. In its fully reduced form, CoQ10 acts as a powerful antioxidant.

CoQ10 is involved in a process called aerobic cellular respiration, which is responsible for about 95% of our energy production. This makes Coenzyme Q10 an extremely important molecule for cellular energy, especially in organs with a high energy demand such as the heart, kidneys and liver.

Different from other antioxidants, CoQ10 inhibits both the initiation and propagation of lipid oxidation as well as protein oxidation. Ubiquinol has also been found to reduce pro-inflammatory genes which can cause severe health problems if inflammation persists. [15]

Typically used for its cardiovascular health benefits, CoQ10 holds many more health benefits due to its link to cellular energy and oxidative damage inhibition.

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Vitamin B2 (riboflavin)

Much like other B Vitamins, riboflavin is involved in a vast number of cellular processes. It plays an integral role in energy metabolism as well as the metabolism of fats, carbohydrates, proteins and ketone bodies.

Riboflavin is commonly found in some food sources, but it is necessary to ensure a sufficient dietary intake of this important vitamin. Vitamin B2 is constantly being excreted from the body in urine, making it essential to continuously supplement.

Dietary-Sources-for-Riboflavin-B2

Vitamin B6 (pyridoxal-5-phosphate)

There are many forms of Vitamin B6, but pyridoxal-5-phosphate or PLP is the active form, making it the most effective when supplemented. Pyridoxal phosphate is involved in many metabolic processes, such as the metabolism of amino acids, glucose and lipids, neurotransmitter synthesis and gene expression.

Low Vitamin B6 levels, based on serum levels of pyridoxal-5-phosphate have been associated with inflammatory diseases such as cardiovascular disease, rheumatoid arthritis and diabetes among others. [16]

Vitamin-B6-food-source

Vitamin B9 Folate (Quatrefolic®)

Folate deficiency is one of the most common nutrient deficiencies. Folic acid is the cheapest and most common form of folate found in many fortified foods and dietary supplements. This is a problem for many people who are incapable of metabolizing folic acid properly. It can also mask a Vitamin B12 deficiency, making it difficult to properly diagnose the deficiency which can lead to many health problems.

(6S)-5-methyltetrahydrofolate is a preferred source of folate due to its distinct advantages over other forms. 5-MTHF is immediately bioavailable, meaning it does not need to be metabolized by the body in order to perform its biologic action.

Individuals with a MTHFR gene mutation can benefit greatly by taking 5-methyltetrahydrofolate over folic acid because of its immediate bioavailability. [17]

Vitamin-B9-Quatrefolic-Folate

Vitamin B12 (methylcobalamin)

Vital for the methylation process and countless cellular processes, it is also important to supplement the correct form of B12. Three distinct forms of Vitamin B12 are available, cyanocobalamin, hydroxocobalamin and methylcobalamin. Many supplements use cyanocobalamin because it is the cheapest form of B12. While each of these forms of B12 yields similar health benefits, the advantage of using methylcobalamin is that it is the most available form of the vitamin. While cyanocobalamin is a man made version which contains small amounts of cyanide. It is not dangerous in recommended amounts, but it does tax the liver, forcing it to process the vitamin and rid the body of the toxic cyanide before it can be utilized.

Methylcobalamin has been shown to improve glutathione status, reduce chronic pain and improve cognitive function, but we believe that is just the tip of the iceberg for this astounding vitamin. [18,19,20]

Vitamin C (calcium ascorbate)

One of the most widely recognized antioxidants, Vitamin C plays many important roles in our body. It is crucial that we regularly intake sufficient amounts of Vitamin C because humans cannot synthesize it on their own.

Vitamin C is needed for the growth and repair of all our tissues and it is plays a key role in the creation of collagen. [21] The role Vitamin C has in collagen synthesis has made it an explosively popular ingredient in anti-aging supplements and cosmetics. It does far more than help people fight the signs of aging though, it is required to make skin, tendons, ligaments and blood vessels. Vitamin C also helps heal wounds, form scar tissue, repair and maintain our cartilage bones and teeth while acting as a powerful antioxidant that fights free radical damage and boosts our immune function. [22]

Vitamin-C

Vitamin K2 (MK-7)

Vitamin K2 deficiency (particularly MK-7) is one of the underlying causes of progressive cardiovascular and bone health deterioration.

Studies have shown that vitamin K is an anticancer, anticalcification, insulin-sensitising molecule that helps with the formation of bones. It’s an essential component for the body to utilize calcium and vitamin D properly. Helping to prevent osteoporosis as well as arterial calcification.

vitamin-k2-immune-health-supplement

Vitamin D3

Known as the sunshine vitamin because humans can synthesize Vitamin D3 (cholecalciferol) when the skin is exposed to sunlight. Unfortunately many people are still deficient in Vitamin D, even if they are getting plenty of time outside, most people in the Northern Hemisphere just cannot get an adequate amount of this sunshine vitamin through sunshine alone. [23]

Vitamin D3 is generally associated with bone health and development due to its ability to promote calcium absorption and maintain adequate serum calcium concentrations. Vitamin D performs many other roles in the body, from modulating cell growth to regulating cell proliferation and apoptosis. This link to cellular health and genetic regulation gives Vitamin D3 a principle role in our immune health and ability to ward off disease. [24]

Vitamin-D3-Glutathione-supplement

Vitamin E

A fat soluble antioxidant that can help stop the reactive oxygen species from forming when fat undergoes oxidation. Helping to prevent oxidative damage and limiting free radical production are two huge benefits of Vitamin E, helping to fight the aging process and a wide number of diseases associated with free radical formation. [25]

Vitamin E is a crucial antioxidant that is involved in numerous metabolic processes including, cell signaling and the regulation of gene expression. It also helps fight disease and infection by acting as an anti-inflammatory and immunity booster.

Vitamin-E-source

1. Ncbi.nlm.nih.gov. Randomized controlled trial of oral glutathione s… [Eur J Nutr. 2014] -PubMed – NCBI. [1]

2. Ncbi.nlm.nih.gov. Mitochondrial glutathione, a key survi… [Antioxid Redox Signal. 2009] – PubMed – NCBI. [2]

3. Ncbi.nlm.nih.gov. Acetylcysteine reduces plasma homocysteine conce… [Circulation. 2004] – PubMed – NCBI. [3]

4. Ncbi.nlm.nih.gov. N-acetyl-L-cysteine (NAC) inhibits virus r… [Biochem Pharmacol. 2010] – PubMed – NCBI. [4]

5. Ncbi.nlm.nih.gov. Effect of alpha-lipoic acid on blood glucose, in… [Saudi Med J. 2011] – PubMed – NCBI. [5]

6. Ncbi.nlm.nih.gov. Effects of alpha-lipoic Acid on body weight in obes… [Am J Med. 2011] – PubMed – NCBI. [6]

7. Ncbi.nlm.nih.gov. Physical activity and alpha-lipoic acid mo… [J Physiol Biochem. 2013] – PubMed – NCBI. [7]

8. Ncbi.nlm.nih.gov. Lipoic acid as an anti-inflammato… [Adv Drug Deliv Rev. 2008 Oct-Nov] – PubMed – NCBI. [8]

9. Ncbi.nlm.nih.gov. Acetyl-L-carnitine reduces depression … [Scand J Gastroenterol. 2011] – PubMed – NCBI. [9]

10. Nicola Longo M. DISORDERS OF CARNITINE TRANSPORT AND THE CARNITINE CYCLE.American journal of medical genetics Part C, Seminars in medical genetics. 2006;142C(2):77. doi:10.1002/ajmg.c.30087. [10]

11. Susanna Scafidi G. Neuroprotection by Acetyl-l-Carnitine after Traumatic Injury to the Immature Rat Brain. Developmental Neuroscience. 2011;32(5-6):480. doi:10.1159/000323178. [11]

12. Ncbi.nlm.nih.gov. Selenium and training effects on the gl… [Med Sci Sports Exerc. 1995] – PubMed – NCBI. [12]

13. Ncbi.nlm.nih.gov. Effects of silymarin MZ-80 on oxid… [Int J Clin Pharmacol Ther. 2002] – PubMed – NCBI. [13]

14. Ncbi.nlm.nih.gov. Effect of silymarin in the treatm… [Otolaryngol Head Neck Surg. 2011] – PubMed – NCBI. [14]

15. Ncbi.nlm.nih.gov. Ubiquinol decreases monocytic expression and D… [BMC Res Notes. 2012] – PubMed – NCBI. [15]

16. Lydia Sakakeeny J. Plasma Pyridoxal-5-Phosphate Is Inversely Associated with Systemic Markers of Inflammation in a Population of U.S. Adults. The Journal of Nutrition. 2012;142(7):1280. doi:10.3945/jn.111.153056. [16]

17. R Prinz-Langenohl K. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase. British Journal of Pharmacology. 2009;158(8):2014. doi:10.1111/j.1476-5381.2009.00492.x. [17]

18. S Jill James D. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. The American Journal of Clinical Nutrition. 2009;89(1):425. doi:10.3945/ajcn.2008.26615. [18]

19. Ming Zhang H. Methylcobalamin: A Potential Vitamin of Pain Killer. Neural Plasticity. 2013;2013. doi:10.1155/2013/424651. [19]

20. Uwe Gröber J. Neuroenhancement with Vitamin B12—Underestimated Neurological Significance.Nutrients. 2013;5(12):5031. doi:10.3390/nu5125031. [20]

21. Ncbi.nlm.nih.gov. Effect of vitamin C and its derivatives on … [Int J Cosmet Sci. 1998] – PubMed – NCBI. [21]

22. Nlm.nih.gov. Vitamin C: MedlinePlus Medical Encyclopedia. [22]

23. Health.harvard.edu. Time for more vitamin D – Harvard Health Publications. [23]

24. Ods.od.nih.gov. Vitamin D — Health Professional Fact Sheet. [24]

25. Ods.od.nih.gov. Vitamin E — Health Professional Fact Sheet. [25]