With so many scholarly articles covering the importance of glutathione, we think it is helpful to compile a short list of some of the most powerful glutathione benefits.


Glutathione Study Summaries

1. Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism

“Glutathione supplementation improved lipid metabolism and acidification in skeletal muscles during exercise, leading to less muscle fatigue.” – Wataru Aoi.


Kyoto University


2. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years

“High blood glutathione concentrations and excellent physical and mental health are characteristics of long-lived women.” – Calvin A. Lang. [2]

University of Louisville


3. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients

“Correction of GSH deficiency is associated with improvement of mitochondrial fat and carbohydrate oxidation in both fasted and fed states and with improvements in insulin sensitivity, body composition, and muscle strength. – Nguyen D. [3]

Baylor College of Medicine


4. Antioxidant status and lipid peroxidation in small intestinal mucosa of children with celiac disease

“The antioxidant capacity of celiac patients is significantly reduced, mostly by a depletion of glutathione. Natural antioxidants and appropriate dietary supplements could be important complements to the classic therapy of celiac disease.” – Stojiljkovic V. [4]

University of Belgrade


5. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

“Children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione,” – James SJ [5]

University of Arkansas


6. Glutathione metabolism and its implications for health

Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathogenesis of many diseases (including kwashiorkor, seizure, Alzheimer’s disease, Parkinson’s disease, liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, heart attack, stroke, and diabetes).” – Wu G. [6]

Texas A&M University


7. Chelation: Harnessing and Enhancing Heavy Metal Detoxification – A Review

Glutathione is another potent chelator involved in cellular response, transport, and excretion of metal cations and is a biomarker for toxic metal overload.” – Margaret Sears. [7]

Children’s Hospital of Eastern Ontario Research Institute


8. Mitochondrial glutathione redox and energy producing function during liver ischemia and reperfusion

“Recovery of the mitochondrial energy-producing function might be closely associated with mitochondrial GSH concentrations.” – Kurokawa T. [8]

Nagoya University School of Medicine


9. Glutathione Metabolism and Parkinson’s Disease

“Glutathione, a ubiquitous thiol tripeptide, provides protection from oxidative stress-induced damage through the reduction of reactive oxygen species.” – Michelle Smeyne [9]

St. Jude Children’s Research Hospital


10. Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

“Over the past several decades the role of intracellular GSH status in neurodegenerative diseases has been studied intensively. Such research continues to provide mechanistic insights pertaining to the cellular dysfunction of the neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and Friedreich’s ataxia. Disruption in GSH homeostasis and modification of the enzymes that are dependant on GSH as a substrate have been linked to initiation and progression of the neurodegenerative diseases.” – William Johnson [10]

Case Western Reserve University


11. Neuroprotective Effect of Reduced Glutathione on Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer

“GSH is a promising drug for the prevention of oxaliplatin-induced neuropathy, and that it does not reduce the clinical activity of oxaliplatin.” – Stefano Cascinu [11]

Azienda Ospedaliera – Universitaria di Parma

GSH Benefits