MTHFR has such a profound effect on the manifestation of these health conditions, yet it is so rarely addressed by medical professionals. Supplementing for MTHFR improves the methylation cycle and in turn, the function of virtually every system.
Folate vs Folic Acid
Folate is the term used for a group of water soluble B Vitamins, also known as B9.
Folic acid refers to the synthetic, oxidized compound that is often found in dietary supplements and foods fortified with Vitamin B9. Folate refers to the tetrahydrofolate derivatives that are naturally present in food.
In 1998, folic acid was introduced as a mandatory food fortification because of its ability to protect against neural tube defects in newborns.
Researchers now believe that long-term consumption of folic acid through supplements and food may relate to an increased risk of cancer and cognitive impairment.
Increased levels of unmetabolized folic acid in the blood is associated with decreased levels of natural killer cells. These natural killer cells play a vital role in tumor cell destruction, suggesting that excessive folic acid intake could promote existing premalignant and malignant tumors.
Folate is an essential cog in the metabolic cycle, the form used is tetrahydrofolate (THF). This tetrahydrofolate is metabolized in the small intestine, while the synthetic folic acid is first processed through the liver, placing a huge burden on the body’s key detoxifying organ.
Sources for Folate
Folate is essential for our health, it aids in the development of red blood cells, reduces homocysteine levels and supports nervous system function. It is commonly characterized by its ability to help prevent neural tube defects, making it a popular supplement for expecting mothers.
Food sources of folate include: spinach, asparagus, lettuce, broccoli, cauliflower, beets, lentils, parsley and liver.
Supplementing your dietary intake with folate is also effective. Look for supplements that contain 5-methyltetrahydrofolate (5-MTHF) and avoid products that use folic acid. Unfortunately most multivitamins use folic acid because it is far more inexpensive.
Nutrient Recommendations for MTHFR
Dr. Lynch is one of the leading experts on MTHFR gene mutations, founding the most popular resource for MTHFR on the web.
His recommended nutrient protocol for C677T MTHFR mutations include: Methylfolate, Methylcobalamin, N Acetyl-L-Cysteine, Glutathione, Pyridoxal-5-Phosphate, Riboflavin, Curcumin, Vitamin E, Silymarin, EPA/DHA (Omega-3), Vitamin C, Vitamin D3 and a Probiotic.
Almost all of which are found in abundance in GSH Gold, making our supplement one of the most complete MTHFR friendly multivitamins.