Glutathione for Fitness

Boosting glutathione levels directly with L-glutathione as well as with precursors and methyl-boosting nutrients is vital, especially for athletes.

Regularly straining your body with intense exercise causes a flood of free radicals. These free radicals run rampant and cause severe oxidative damage to our body.

Promoting antioxidant activity in the body can help to neutralize free radicals and repair damage to our cells and tissue. This can have dramatic benefits for individuals who regularly undergo physical stress, helping to reduce recovery times and optimize energy levels.

GSH Gold Fitness Benefits

Glutathione (GSH)

Glutathione (GSH) is vital for maintaining optimal immune function and cellular health. Found in every cell in the body, it is found in highest concentrations in our liver, heart and muscle tissue.

Popularly associated with our immune health, toxicity level and general well-being for its plethora of health benefits, glutathione also has numerous fitness benefits.

Glutathione may help improve muscular strength and physical endurance by warding off fatigue, but its ability to repair our body is what makes it a must for fitness enthusiasts. [1] GSH is directly involved in repairing damage caused by oxidative stress, something that floods throughout the body during an intense workout. [2]

Due to the direct relationship between glutathione and the body’s healing process, many experts believe gym goers and athletes should supplement their glutathione levels. Not only will increased GSH levels combat oxidative damage, improving glutathione levels may reduce recovery times and allow for maximum benefits post workout. [3]

N Acetyl-L-Cysteine (NAC)

N Acetyl-L-Cysteine (NAC) is another powerful antioxidant with countless health benefits. One of the many benefits of NAC is its ability to significantly improve glutathione status. GSH is made up of glycine, glutamic acid and cysteine; the rate limiting factor for endogenous glutathione production is cysteine.

Treating acute liver toxicity due to acetaminophen overdose is one of the more common clinical uses for N Acetylcysteine, it is also a popular anti mucolytic agent. Preventing mucus buildup that can lead to trouble breathing and severe coughing fits.

Fitness benefits of supplementing with NAC are quite similar to those of glutathione, partially due to their close relationship. N Acetylcysteine is beneficial for reducing oxidative stress brought on by physical activity. [4,5] NAC may also help reduce respiratory muscle fatigue and delay overall muscle fatigue during prolonged exercise. [6,7,8]

Alpha Lipoic Acid (ALA)

Most antioxidants are either fat or water soluble, preventing them from functioning throughout the entire body. Alpha Lipoic Acid (ALA) is both fat and water soluble, granting it the ability to work throughout the body. It also has the unique ability to regenerate itself and certain other antioxidants after they are used up and in their oxidized form.

Alpha lipoic acid mimics insulin, ushering glucose into the cell to be burned up for energy. This not only helps to enhance weight loss by using up excess glucose that would otherwise be stored as fat, it also enhances cellular energy production. These characteristics have made alpha lipoic acid extremely beneficial for individuals with diabetes and those looking to optimize weight loss efforts. [9]

Supplementing with alpha lipoic acid may significantly improve glucose uptake of muscle cells, thereby improving energy production. Acting as a powerful antioxidant as well, ALA is great for athletes, bodybuilders and fitness enthusiasts looking to get the most out of their workouts and quickly repair the damage caused by oxidative stress. [10]

Acetyl L-Carnitine (ALC)

Known for its neuroprotective and cognitive benefits, Acetyl L-Carnitine (ALC) does more than just boost our brain health.

Studies show that supplementing with ALC may help decrease both physical and mental fatigue during physical activity. Mental fatigue is an extremely common problem, reaching far beyond individuals who exercise regularly. Many people rely on stimulants like caffeine in order to maintain cognitive function throughout the day, acetyl l-carnitine accomplishes this naturally and effectively. [11,12,13]

The combined effects of Acetyl L-Carnitine and Alpha Lipoic Acid have been thoroughly studied. Researchers have found significant health benefits and particularly brain health benefits from supplementing these two antioxidants together. Targeting mitochondrial dysfunction, the combined effects of these antioxidants may be an effective treatment to delay the brains aging process. [14]

Ubiquinol Coenzyme Q10 (CoQ10)

Coenzyme Q10 (CoQ10) is synonymous with cellular energy. Found in its highest concentrations in tissue and organs that require the most energy and  therefore have the highest rate of metabolism. Organs with the highest concentrations of CoQ10 include the heart, liver and kidneys, all extremely important for athletic performance and detoxifying the body.

A powerful antioxidant, CoQ10 can help to prevent the increase in lipid peroxidation during bouts of intense exercise. [15] This is important to prevent cellular damage which can inhibit the body’s ability to produce energy and combat free radicals.

Athletes and bodybuilders know CoQ10 well, as it helps to improve the subjective fatigue sensation during physical activities as well as helps to reduce exercise induced muscular injuries. [16,17] The physical performance benefits of CoQ10 are astounding, so it is no wonder it has been a staple supplement for elite athletes, but these benefits are important for everyone, not just fitness enthusiasts. [18]

Full GSH Gold Ingredient List

Hernández, A., Cheng, A. and Westerblad, H. (2012). Antioxidants and Skeletal Muscle Performance: “Common Knowledge” vs. Experimental Evidence. Frontiers in Physiology, [online] 3. Available at: [1]

Kelly, M., Wicker, R., Barstow, T. and Harms, C. (2009). Effects of N-acetylcysteine on respiratory muscle fatigue during heavy exercise. Respiratory Physiology & Neurobiology, [online] 165(1), pp.67-72. Available at: [6]

Kerksick, C. and Willoughby, D. (2005). The Antioxidant Role of Glutathione and N-Acetyl-Cysteine Supplements and Exercise-Induced Oxidative Stress. J Int Soc Sports Nutr, [online] 2(2), p.38. Available at: [2]

Koh, E., Lee, W., Lee, S., Kim, E., Cho, E., Jeong, E., Kim, D., Kim, M., Park, J., Park, K., Lee, H., Lee, I., Lim, S., Jang, H., Lee, K. and Lee, K. (2011). Effects of Alpha-Lipoic Acid on Body Weight in Obese Subjects. The American Journal of Medicine, [online] 124(1), pp.85.e1-85.e8. Available at: [9]

Kon, M., Tanabe, K., Akimoto, T., Kimura, F., Tanimura, Y., Shimizu, K., Okamoto, T. and Kono, I. (2008). Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10. BJN, [online] 100(04). Available at: [17]

Long, J., Gao, F., Tong, L., Cotman, C., Ames, B. and Liu, J. (2008). Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine. Neurochem Res, [online] 34(4), pp.755-763. Available at: [14]

Malaguarnera, M., Vacante, M., Giordano, M., Pennisi, G., Bella, R., Rampello, L., Malaguarnera, M., Li Volti, G. and Galvano, F. (2011). Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. American Journal of Clinical Nutrition, [online] 93(4), pp.799-808. Available at: [11]

Marí, M., Morales, A., Colell, A., García-Ruiz, C. and Fernández-Checa, J. (2009). Mitochondrial Glutathione, a Key Survival Antioxidant. Antioxidants & Redox Signaling, [online] 11(11), pp.2685-2700. Available at: [3]

Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O. and Watanabe, Y. (2008). Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition, [online] 24(4), pp.293-299. Available at: [16], (2014). N-acetylcysteine supplementation contro… [Oxid Med Cell Longev. 2011] – PubMed – NCBI. [online] Available at: [5], (2014). N-acetylcysteine attenuates the decline in muscle … [J Physiol. 2006] – PubMed – NCBI. [online] Available at: [7], (2014). N-acetylcysteine reduces the exacerbatio… [Respiration. 1999 Nov-Dec] – PubMed – NCBI. [online] Available at: [8], (2014). The supplementation of acetyl-L-ca… [J Interferon Cytokine Res. 2011] – PubMed – NCBI. [online] Available at: [12], (2014). Acetyl-L-carnitine reduces depression … [Scand J Gastroenterol. 2011] – PubMed – NCBI. [online] Available at: [13], (2014). Oxidative stress and antioxidant d… [J Sports Med Phys Fitness. 2011] – PubMed – NCBI. [online] Available at: [15], (2014). Biochemical rationale and the cardi… [Proc Natl Acad Sci U S A. 1985] – PubMed – NCBI. [online] Available at: [18]

Nur, E., Brandjes, D., Teerlink, T., Otten, H., Oude Elferink, R., Muskiet, F., Evers, L., ten Cate, H., Biemond, B., Duits, A. and Schnog, J. (2012). N-acetylcysteine reduces oxidative stress in sickle cell patients. Ann Hematol, [online] 91(7), pp.1097-1105. Available at: [4]

Shay, K., Moreau, R., Smith, E., Smith, A. and Hagen, T. (2009). Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta (BBA) – General Subjects, [online] 1790(10), pp.1149-1160. Available at: [10]